PanAir Cargo, a trademark of Cargo Three, Inc, commenced operations in 1991. In addition to its main operational base located at Tocumen International Airport in Panama City, PanAir Cargo has offices in the major cities of Central America, Latin America and the Caribbean.
The airline operates two 22-tonne capacity Boeing 727-200F aircraft and six Convair 580s to provide regional cargo services as well as supporting trade between the Americas and Europe. Its network offers all-cargo services to Bogota, Cape Verde, Caracas, Costa Rica, Dominican Republic, Guatemala, Honduras, Mexico, Myanmar, Panama and Venezuela.